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Search Results for " muscarinic acetylcholine receptor m3 "

Targets Recommended: Potassium Channel AChR

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Cat. No.	Product Name	Target	Signaling Pathways
T1049	Oxybutynin chloride Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Oxybutynin chloride (Oxybutynin HCl) 是一种抗胆碱能药物，用于缓解泌尿和膀胱困难。它抑制血管 Kv 通道，IC50为 11.51 μM。
T8219	VU0238441	AChR	Neuroscience
	VU0238441是一种泛毒蕈碱型乙酰胆碱受体阳性变构调节剂，对 M1、M2、M3、M5 和 M4 的EC50分别为 3.2、2.8、2.2、2.1 和大于 10 μM。
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T16758	Rispenzepine	Others	Others
	Rispenzepine 是一种新型的毒蕈碱型乙酰胆碱受体（mAChRs)的拮抗剂，选择性地靶向M1 和 M3 受体亚型，可用于治疗免疫系统疾病、感染、呼吸系统疾病。
T23763	Atropine Oxide NSC 72861,NSC72861,NSC-72861
	Atropine Oxide is a derivative of Atropine. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5. Atropine is a medication to treat certain types of nerve agents and pesticide poisonings as well as som
T37728	Methoctramine (hydrate)
	Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit...
T69232	Atropine Oxide Hydrochloride
	Atropine Oxide is a derivative of Atropine. Atropine is a medication to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate and to decrease saliva production during surgery. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. It is classified as an anticholinergic drug (parasympatholytic).
T36241	Arecaidine propargyl ester (hydrobromide)
	Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0.977, and 0.933 μM, respectively). Arecaidine propargyl ester induces contractions in isolated guinea pig atrium (pD2= 8.67). It induces apoptosis and the production of reactive oxygen species (ROS) in U87 and U251 glioblastoma cells when used at a concentration of 100 μM.2Arecai...

化合物

Oxybutynin chloride

Cat.No: T1049

Synonym: Oxybutynin hydrochloride,盐酸奥昔布宁,Oxybutynin HCl

Target: Potassium Channel, AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Synonym: NSC 72861,NSC72861,NSC-72861

Target:

Methoctramine (hydrate)

Cat.No: T37728

Synonym:

Target:

Atropine Oxide Hydrochloride

Cat.No: T69232

Synonym:

Target:

Arecaidine propargyl ester (hydrobromide)

Cat.No: T36241

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T0804	Pilocarpine Hydrochloride NSC 5746 HCl,盐酸毛果芸香碱,Pilocarpine HCl,(+)-Pilocarpine hydrochloride	AChR	Neuroscience
	Pilocarpine Hydrochloride (NSC 5746 HCl) 是一种 M3 型毒蕈碱乙酰胆碱受体激动剂，用于制作癫痫实验模型

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Pilocarpine Hydrochloride

Cat.No: T0804

Synonym: NSC 5746 HCl,盐酸毛果芸香碱,Pilocarpine HCl,(+)-Pilocarpine hydrochloride

Target: AChR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01716	CHRM3 Protein, Human, Recombinant (B2M & His) Muscarinic acetylcholine receptor...	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM3 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 40.7 kDa and the accession number is P20309.

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CHRM3 Protein, Human, Recombinant (B2M & His)

Cat.No: TMPH-01716

Species: Human

Expression System: E. coli

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